Anyone have any luck using mudfish with league of legends after the vanguard update?

For Riot games (League of Legends) I recommend using the subnet mode rather.

Riot Games uses an anycast proxy which they announce at various exchanges. Here is a list of anycast subnets I have and the locations I know they are hosted in.

MENA - Middle East - Dubai - 162.249.75.0/24 hosted in Dubai announced in Paris, Amstedam and Linx

EUW - Germany Frankfurt - 162.249.72.0/24 hosted in Frankfurt but announced in Amsterdam, Paris, Madrid, London etc

RAZIL - Brazil Sao Paulo - 45.7.37.0/24 hosted in Sao Paulo

NA1 - USA Chicago - 192.207.0.0/24

So on Mudfish make a custom Item and then just add the subnet of the region you are playing on. Select a mudfish node that gives you the best latency to that city rather than a mudfish node close to you because of the anycast proxy Riot is sending these subnets to various exchanges and they don’t always have the lowest latency.