Is there a reason why the MTU value cant be set over 1450? I was doing an MTU ping of the ESO server in the US and getting an optimal setting of 1476 (1448+28)
It’s a VPN. It means it adds some payload in front of the original. 
So 50 bytes are used for mudfish.
So, should i keep the MTU on my router/laptop set to 1500 or also to 1450?
You don’t need to change the values at your router and laptop at all.